Some melanoma cancer cells may punch their way through the body

Cell membrane protrusions called “blebs” act as fists to help melanoma cells tunnel

A greyish mass with a collection of protruding red blobs moves through 3D-looking yellow webbing on a black background

A cancer cell (blob at right in this 3D rendering) can “punch” its way through a tunnel of tissue (yellow) by extending and retracting blebs (red) through cytoskeletal cracks.

M.K. Driscoll et al/Developmental Cell 2024

Imagine tiny fists punching their way through your body.